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Company news about How to select the right vacuum shear emulsifier for ointment production?

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How to select the right vacuum shear emulsifier for ointment production?

2026-01-12

How to select the right vacuum shear emulsifier for ointment production?

Selecting a vacuum shear emulsifier for ointment production requires matching equipment specifications to formulation characteristics and production needs. Key considerations include:
Rotor-stator structure: Ointments (especially high-viscosity types) require a multi-stage rotor-stator system (2-3 stages) to generate sufficient shear force. A maximum rotational speed of 12,000-15,000 rpm and linear speed of 45-50 m/s ensure particle size is reduced to ≤5 μm.
Vacuum performance: A vacuum degree of ≥-0.095 MPa is necessary to remove air bubbles effectively, especially for ointments with sensitive active ingredients prone to oxidation. The vacuum system should integrate seamlessly with the mixing chamber to avoid air re-entry.
Temperature control: Ointment matrices (e.g.,凡士林, lanolin) and active ingredients are often temperature-sensitive. A jacketed temperature control system with precision ±1℃, adjustable between 20-60℃, prevents thermal denaturation.
Material and hygiene: All product-contacting parts must be 316L stainless steel with electrolytic polishing to avoid material adhesion and cross-contamination. CIP compatibility is essential for pharmaceutical production to meet GMP requirements.
Scalability: Modular designs that support batch volumes from laboratory-scale (10-50 L) to industrial-scale (500-5,000 L) allow for seamless transfer from pilot tests to mass production.
Control system: An automatic touchscreen system with real-time parameter recording (temperature, speed, vacuum degree, emulsification time) supports data traceability, critical for pharmaceutical batch documentation.
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Company news about-How to select the right vacuum shear emulsifier for ointment production?

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How to select the right vacuum shear emulsifier for ointment production?

2026-01-12

How to select the right vacuum shear emulsifier for ointment production?

Selecting a vacuum shear emulsifier for ointment production requires matching equipment specifications to formulation characteristics and production needs. Key considerations include:
Rotor-stator structure: Ointments (especially high-viscosity types) require a multi-stage rotor-stator system (2-3 stages) to generate sufficient shear force. A maximum rotational speed of 12,000-15,000 rpm and linear speed of 45-50 m/s ensure particle size is reduced to ≤5 μm.
Vacuum performance: A vacuum degree of ≥-0.095 MPa is necessary to remove air bubbles effectively, especially for ointments with sensitive active ingredients prone to oxidation. The vacuum system should integrate seamlessly with the mixing chamber to avoid air re-entry.
Temperature control: Ointment matrices (e.g.,凡士林, lanolin) and active ingredients are often temperature-sensitive. A jacketed temperature control system with precision ±1℃, adjustable between 20-60℃, prevents thermal denaturation.
Material and hygiene: All product-contacting parts must be 316L stainless steel with electrolytic polishing to avoid material adhesion and cross-contamination. CIP compatibility is essential for pharmaceutical production to meet GMP requirements.
Scalability: Modular designs that support batch volumes from laboratory-scale (10-50 L) to industrial-scale (500-5,000 L) allow for seamless transfer from pilot tests to mass production.
Control system: An automatic touchscreen system with real-time parameter recording (temperature, speed, vacuum degree, emulsification time) supports data traceability, critical for pharmaceutical batch documentation.
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